Lee, Joonsung, Tang, Jonathan C. Y. ORCID: https://orcid.org/0000-0001-6305-6333, Dutton, John, Dunn, Rachel, Fraser, William D., Enright, Kevin, Clark, David R., Stewart, Claire E. and Erskine, Robert M. (2025) Effects of resistance exercise, collagen ingestion and circulating oestrogen concentration on collagen synthesis in a female athlete: A case report. Experimental Physiology, 110 (11). pp. 1569-1575. ISSN 0958-0670

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Abstract

We investigated the effects of resistance exercise (RE), hydrolysed collagen (HC) ingestion and circulating oestrogen concentration on collagen synthesis in a naturally menstruating female CrossFit athlete. In a double-blind, randomised cross-over design, the participant (36 years; height 1.61 m; mass 82.6 kg) consumed 0 or 30 g HC prior to performing back-squat RE when endogenous circulating oestrogen concentration was low (onset of menses, OM) and high (late follicular phase, LF) during two consecutive menstrual cycles. Ten 5-mL blood samples were collected during each of the four interventions to analyse concentrations of serum 17β-oestradiol, and biomarkers of type I collagen turnover, that is serum procollagen type I N-terminal propeptide (PINP, a biomarker of collagen synthesis) and plasma β-isomerised C-terminal telopeptide of type I collagen (β-CTX, a biomarker of collagen breakdown), as well as the serum concentration of 18 collagen amino acids. 17β-Oestradiol concentration was 5-fold higher at LF (891 ± 116 pmol L −1) than OM (180 ± 13 pmol L −1). The PINP concentration × time area under the curve (AUC) was higher in the 30 g HC OM intervention (201 μg L −1 h) than the 30 g HC LF (144 μg L −1 h), 0 g HC OM (151 μg L −1 h) and 0 g HC LF (122 μg L −1 h) interventions. β-CTX concentration decreased 1.4-fold from pre-RE to 6 h post-RE in all interventions. Thus, high circulating oestrogen concentration was associated with lower collagen synthesis following RE in this female athlete. Ingesting 30 g HC, however, augmented the collagen synthesis response at LF and particularly at OM.

Item Type:	Article
Additional Information:	Special Issue: Physiology and the Olympics. DATA AVAILABILITY STATEMENT: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Uncontrolled Keywords:	female,connective tissue,glycine,proline,estrogen,oestrogen,physiology (medical),nutrition and dietetics,physiology ,/dk/atira/pure/subjectarea/asjc/2700/2737
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	07 Jun 2024 08:30
Last Modified:	27 Sep 2026 13:16
URI:	https://uea-test-2026.eprints-hosting.org/id/eprint/95401
DOI:	10.1113/EP091897

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