Kelemen, Gabriella H., Zalacain, Magdalena, Culebras, Esther, Seno, Eugene T. and Cundliffe, Eric (1994) Transcriptional attenuation control of the tylosin‐resistance gene tlrA in Streptomyces fradiae. Molecular Microbiology, 14 (4). pp. 833-842. ISSN 0950-382X

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Abstract

The tylosin producer Streptomyces fradiae contains four known resistance genes, two of which (tlrA and tlrD) encode methyltransferases that act on ribosomal RNA at a common site. Expression of tlrA is regulated via transcriptional attenuation. A short transcript, only 411 nucleotides long, terminates 27 nucleotides into the methylase‐coding sequence in the uninduced state. Induction of tlrA is proposed to involve a ribosome‐mediated conformational change within the mRNA leader that allows transcription to continue beyond the attenuation site, resulting in a transcript about 1450 nucleotides long. Transplantation of tlrD and/or tlrA into Streptomyces albus revealed that the induction specificity of tlrA depends upon the state of the ribosomes and is significantly altered in strains also expressing tlrD.

Item Type:	Article
Uncontrolled Keywords:	microbiology,molecular biology ,/dk/atira/pure/subjectarea/asjc/2400/2404
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Molecular Microbiology
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	19 Jul 2022 16:30
Last Modified:	16 Jun 2026 18:07
URI:	https://uea-test-2026.eprints-hosting.org/id/eprint/86644
DOI:	10.1111/j.1365-2958.1994.tb01319.x

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